The title characters of the series are a family of machine-enhanced human beings possessing unique powers after being augmented with bionic technology, much like The Six Million Dollar Man and The Bionic Woman. Each family member is given specific bionic powers, and thus they form a superhero team named Bionic Six.
In the near future (some unspecified decades after 1999), Professor Sharp, head of the Special Projects Labs (SPL), creates a new form of technology to augment humans through bionics. His first subject was Jack Bennett, a test pilot who secretly acted as Sharp's field agent, Bionic-1. On a family ski vacation in the Himalayas, an alien spacecraft triggers an avalanche that buries the entire family, exposing them to the unusual radiation of a mysterious buried object. Jack frees himself but discovers his family in a comatose state. Theorizing that Jack's bionics protected him from the radiation, Professor Sharp implants bionic technology in the others, awakening them. Afterward, the family operates incognito as a publicly lauded team of adventuring superheroes, the Bionic Six.