Jake Kong, Eddie Spencer and Tracy the Gorilla are The Ghost Busters. Jake and Eddie Jr are the sons of the original Ghost Busters from the live action series of the same name; Tracy worked with their fathers. Their headquarters, termed Ghost Command, is located in a haunted mansion nestled between a number of tall skyscrapers (which resemble the World Trade Center's Twin Towers in New York City) They are supported by a number of secondary characters including Ansa-Bone, a talking skull phone; Skelevision, a talking skeleton television; Belfrey, a pink talking bat; and Ghost Buggy, their talking ghost car. They occasionally enlist the aid of Futura, a time travelling Ghostbuster from the future, and Jessica, a local TV news reporter. Together, they have dedicated themselves to ridding the world of the evil ghost wizard Prime Evil and his cast of henchmen.
Prime Evil's headquarters, termed Hauntquarters (which resembles the British Houses of Parliament complete with a Big Ben-esque clock tower), is located in The Fifth Dimension. In a typical episode, Prime Evil uses his magical powers to open up a wormhole to enable one or more of his henchmen to complete a particular scheme that serves to help him take over the world.