Based upon the DC Comics character and like previous film incarnations of Swamp Thing, the animated series rejects the popular Alan Moore revision of Swamp Thing's origin and portrays him with his original origin as a man turned into a plant-like entity. Anton Arcane takes the role of the main villain responsible for Alec Holland's transformation into Swamp Thing. Arcane is backed by his gang of Un-Men: Dr. Deemo, Weedkiller, and Skinman. Swamp Thing also has two friends named Tomahawk and Bayou Jack. Tomahawk is Native American not to be confused with the DC/Vertigo character, Thomas Hawk, who was a soldier in the American Revolution rescued by Native Americans. Bayou Jack is a Vietnam veteran.
Similar to Troma's Toxic Crusaders, the animation style of Swamp Thing follows the trend of goofy, horror anti-heroes made for the children. Spoofing Chip Taylor's "Wild Thing," the opening theme plays "Swamp Thing! ...You are amazing!" The series also bears an environmentally conscious side also noted in many of its contemporaries.